Diagnostic value of five serum tumor markers in lung cancer

Objective To explore the diagnostic value of serum CA125,CA153,neuron-specific enolase(NSE),car-cinoembryonic antigen(CEA) and CYFRA21-1 in lung cancer.Methods Five serum tumor markers levels were de-tected by chemiluminescence immunoassay and samples came from 62 patients with lung cancer and 52 patients withbenign lung diseases patients and 46 normal adults.The diagnosis sensitivity and specificity were analyzed respective-ly.Results Serum tumor markers levels in lung cancer group were significantly higher than those in control group(P 0.001).Four serum tumor markers(except for CA125) levels in lung cancer group were significantly higher thanthose in benign lung diseases patients(P 0.01).The positive ratio of five tumor markers were significantly higherthan those in benign lung diseases patients and normal adults(P 0.005).CYFRA21-1,CEA and NSE appeared thehighest positive ratio in squamous cell carcinoma(76.92%),adenocarcinoma(70.83%) and small cell lung cancer(75.0%) respectively.Those tumor markers combined measurement may be more sensitive in lung cancer(P 0.01).Conclusion The combined determination of serum tumor markers could significantly improve the sensitivityand specificity in the diagnosis and classification of lung cancer.