The clinical significance of combined detection of serum tumor markers levels in diagnosis and therapeautic evaluation of pancreatic carcinoma

Objective To explore the clinical significance of combined detection of serum CA199、CA242、CA125、CEA and OPN levels in diagnosis and therapeautic evaluation of pancreatic carcinoma.Methods Detection of Serum tumor markers CA199、CA242、CA125、CEA and OPN Were carried out in 41 patients with pancreatic carcinoma and 40 healthy volunteer,and in pancreatic cancer group these tumor markers were detect-ed before operation and 1 month after operation.The sensitivity,specificity and accuracy of the detection in pancreatic cancer diagnosis were calcu-lated.Results The concerntrations of these tumor markers and the positive ratio in the patients with pancreatic cancer were significantly higher than those in the normal controls,The concentrations of the five markers of preoperation are higher than that of postoperation,and difference was sta-tistically significant (all P0.05).If serum CA199,CA242,CA125,CEA and OPN were detected simultaneously,the sensitivity and specificity in di-agnosis of pancreatic cancer could be improved,and sensitivity of CA199 is the highest among those markers.Conclusion The combined detection of serum CA199,CA242,CA125,CEA and OPN levels has better clinical value in diagnosis,therapeutic effect evaluation and prognosis prediction.