Effect of Fluvastatin on Ventricular Remodeling and Expression of MMP-9 and MMP-10 in Acute Myocardial Infarction Rats

Aim To study the effect of fluvastatin on cardiac remodeling and cardiac function,and to investigate the effect of matrix metalloproteinase-9(MMP-9) and MMP-10. Methods 36 Wistar rats were randomly divided into acute myocardial infarction(AMI) group,AMI + fluvastatin group and the sham-operated group. AMI was established by ligation of the anterior descending coronary artery in rats,fluvastatin was fed to AMI + fluvastatin group by 20 mg /( kg·d) for 6 weeks. After 6 weeks treatment,then the hemodynamic parameters and mass index of left ventricular and the expression of MMP-9 and MMP-10 were detected. Results Compared with the sham-operated group,left ventricular systolic pressure(LVSP) and the maximal rate of rise and fall( ± dp /dtmax) of left ventricular pressure in the AMI group and AMI + fluvastatin group were all decreased( P 0. 05),moreover,these indexes decreased significantly in AMI group than those in AMI + fluvastatin group(P 0. 05). Compared with the sham-operated group,left ventricular end-diastolic diameter(LVEDD),left ventricular end systolic diameter( LVESD),left ventricular mass index( LVMI),MMP-9,MMP-10 were significantly increased in the AMI group and AMI + fluvastatin group; moreover,these indexes decreased in AMI + fluvastatin group than those in AMI group(P 0. 05). Conclusion Fluvastatin could prevent the cardiac remodeling,the mechanisms may be by reducing the levels of MMP-9 and MMP-10.