2007•Journal of Cardiovascular and Pulmonary DiseasesRequires access
Effect of fluvastatin on the expression of myocardial MCP-1 in rats with heart failure after acute myocardial infarction
Qiutang Zeng
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Abstract
Objective:To investigate the effect of fluvastatin on the expression of monocyte chemotactic protein-1(MCP-1)mRNA of myocardial tissue in rats with heart failure after acute myocardial infarction(AMI)Method:Six hours after ligating left coronary artery,surviving AMI female SD rats were randomly assigned to:1.AMI control;2.fluvastatin;3.sham-operated group are selected randomly as non-infarction control.After 8 weeks of therapy,We assessed cardiac function,hemodynamics,ventricular remodeling parameters,MCP-1 mRNA in left ventricular(LV)non-infarcted area(NIA).Result:Compared with sham-operated group,LV end-diastolic dimension(LVEDD),LV end-diastolic volume(LVEDV),E-wave,E-wave deceleration,E/A ratio,LV end diastolic pressure(LVEDP),relative weight(LVRW),right ventricular relative weight(RVRW),collagen volume fraction(CVF)and MCP-1 mRNA in NIA were all significantly increased in AMI group(P0.01),while fractional shortening(FS)and ejection fraction(EF)were all significantly decreased(P0.01).In comparison with AMI group,LVEDD,LVEDV,E-wave,E-wave deceleration,E/A,LVEDP,LVRW,RVRW,CVF and MCP-1 mRNA were all significantly decreased(P0.01),while FS and EF were all significantly increased in fluvastatin group(P0.01).Conclusion:Fluvastatin can attenuate LV remodeling and heart failure after AMI in the rat,Partly through down-regulating the expression of MCP-1 mRNA and improving inflammatory response.