2005Yixue fenzi shengwuxue zazhiRequires access

Advances in Gene Therapy: Adeno-Associated Virus (AAV) Vectors

He Chengwei

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Abstract

Adeno-associated virus (AAV) vectors show great promise for gene therapy.The extensive application of this vector system in the basic medical sciences and clinical practice, however, is limited by their biological properties.This study explored the possibilities of expanding their use by introducing new techniques of packaging, production, purification and speeding-limiting method in AAV transduction.

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What this paper is about

Adeno-associated virus (AAV) vectors show great promise for gene therapy.The extensive application of this vector system in the basic medical sciences and clinical practice, however, is limited by their biological properties.This study explored the possibilities of expanding their use by introducing new techniques of packaging, production, purification and speeding-limiting method in AAV transduction.

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Available abstract

Adeno-associated virus (AAV) vectors show great promise for gene therapy.The extensive application of this vector system in the basic medical sciences and clinical practice, however, is limited by their biological properties.This study explored the possibilities of expanding their use by introducing new techniques of packaging, production, purification and speeding-limiting method in AAV transduction.

Key concepts: Adeno-associated virus, Transduction (biophysics), Genetic enhancement, Limiting, Vector (molecular biology), Gene transfer, Virology, Biology

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