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Adeno-associated Virus and AAV Vectors for Gene Delivery

Barrie J. Carter, Haim Burstein, Richard W. Peluso

Open publisher page 33 citations

Abstract

I. INTRODUCTION In this chapter we summarize the state of development of adeno-associated virus (AAV) vectors and provide an overview of AAV as well as some historical comment on early seminal studies that are generally overlooked in current reviews. We do not attempt to provide an exhaustive collection of references on development of AAV vectors but do discuss the key advances in the last several years, including improvements in vector production and studies on the applications for persistent gene expression. Other references provide general reviews of AAV (1,2) and extensive summaries on earlier development of AAV vectors (3-7).

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I. INTRODUCTION In this chapter we summarize the state of development of adeno-associated virus (AAV) vectors and provide an overview of AAV as well as some historical comment on early seminal studies that are generally overlooked in current reviews. We do not attempt to provide an exhaustive collection of references on development of AAV vectors but do discuss the key advances in the last several years, including improvements in vector production and studies on the applications for persistent gene expression. Other references provide general reviews of AAV (1,2) and extensive summaries on earlier development of AAV vectors (3-7).

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Available abstract

I. INTRODUCTION In this chapter we summarize the state of development of adeno-associated virus (AAV) vectors and provide an overview of AAV as well as some historical comment on early seminal studies that are generally overlooked in current reviews. We do not attempt to provide an exhaustive collection of references on development of AAV vectors but do discuss the key advances in the last several years, including improvements in vector production and studies on the applications for persistent gene expression. Other references provide general reviews of AAV (1,2) and extensive summaries on earlier development of AAV vectors (3-7).

Key concepts: Adeno-associated virus, Virology, Gene delivery, Vector (molecular biology), Biology, Virus, Gene, Genetic enhancement

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