CLINICAL ANALYSIS OF 129 CASES OF ACUTE DRUG-INDUCED LIVER INJURY

Objective To investigate the clinical manifestation,classification,causative drugs,therapy and the prognosis of acute drug-induced liver injury to guide clinical diagnosis and therapy.Methods 129 inpatients with acute drug-induced liver injury in the past five years were retrospectively investigated with the causality assessment method of acute drug-induced liver diseases based on the latest domestic criteria.Results No obvious symptoms and signs are shown in 45.74% cases.In this study,97(75.19%),18(13.95%),14(10.85%)cases are classified hepatocellular,cholestetic and mixed type accordingly while 5 cases are diagnosed as severe liver injury.Many drugs can cause liver injury,in this study,the most common ones are antituberculosis drugs,Chinese traditional and herbal drugs and antibiotic drugs.Most of the cases(86.05%)recovered in 30 days after withdrawal of the causative drug(s) and giving proper supportive therapy though 5 cases developed into severe liver injury and have unfavorable prognosis.Conclusion The symptoms of acute drug-induced liver injury are unspecific,so the diagnosis should not base on it.In this study,the most common classification is hepatocellular.Many drugs can cause acute liver injury,so monitoring liver function is necessary when using these kinds of drugs.The prognosis is usually good in this study,but severe liver injury can also occurs,so steps should be taken to handle this.