Effect of Intensive Lipid Lowering by Atorvastain on Carotid arterial Intima-Media Thickness in Patients with Hypertension

Objective To investigate the effect of intensive lipid lowering of atorvastain on carotid intima-media thickness(CIMT) in patients with hypertension.Methods Total 126 hypertensive patients with carotid atheroma were randomized to atorvastatin 40mg/day A group (n=65) and 10mg/day B group (n=61) for six months.The carotid artery inner-intermediate thickness(CIMT) and the speckle’s size were examined by the color Doppler,and blood lipids,liver enzyme and muscle enzyme were detected.Results After six months of treatment,CIMT was obviously decreased in both atorvastatin 40mg/ day A group and 10mg/day B group,which could be further decreased in A group than B group.The levels of TC,and LDL-C in both groups were decreased after treatment.Furthermore,the changes in A group were more obvious than in B group.No more side effect was found in 40mg/day atorvastatin group.Conclusion Intensive treatment by atorvastain can more obviously decrease TC and LDL-C and prevent the progress of carotid atheroma in hypertension patients safely.