One case of toxic epidermal necrolysis induced by imipenem and cilastatin sodium

One 48-year-old male patient with head trauma surgery was hospitalized because of unconsciousness for 1 month. The patient had no drug and food allergic history. After the evacuation of hematoma by craniotomy in emergency, the patient was fever, and the cefoxitin was used according to the susceptibility test. After 5 days, cefoxitin was discontinued, and the antibacterial agent was adjusted to imipenem and cilastatin sodium. Three days later, red rash appeared mainly in the patient's back and chest, and gradually spread to the whole body with peeling. Patient was diagnosed with toxic epidermal necrolysis. Then imipenem and cilastatin sodium was stopped, cefoperazone and sulbactam sodium and fosfomycin sodium were used for anti-infection, and methylprednisolone sodium succinate and other antiallergic treatments were given. Since then, no new rash appeared, skin wound gradually dried, and lesion area gradually diminished.