Cyclooxygenase-2 Protein Expression and Clinic Significance in Human Laryngeal Squamous Cell Carcinoma

【Objective】To investigate the cyclooxygenase-2 protein expression and clinical significance in human laryngeal squamous cell carcinoma,at the same time,to investigate its expression in human laryngeal papilloma and vocal cord polyps.【Methods】Thirty-eight samples of laryngeal squamous cell carcinoma,seven samples of laryngeal papilloma and ten samples of vocal cord polyps were assayed using immunohistochemical SP method for detection of COX-2 protein expression level.【Results】 The COX-2 protein expression level in laryngeal carcinoma was significantly higher than that in vocal cord polyps(P0.01);the expression level in laryngeal papilloma was significantly higher than that in vocal cord polyps(P0.01).In histological classification of the laryngeal carcinoma group,the COX-2 protein expression level in high histological differentiation was significantly higher than that in middle differentiation(P0.01)and low differentiation(P0.01);the COX-2 protein expression level in middle histological differentiation was significantly higher than that in low differentiation(P0.01);there was no significant difference in clinical stages、tumor classification、lymphnode metastasis,tumor site and patient age(P0.05).【Conclusion】 ①COX-2 protein is associated with histological differentiating degree of human laryngeal squamous cell carcinoma.②COX-2 protein perhaps has definite effects in the children' papilloma recurrence and the adults' papilloma ocurrence.