Relationship between serum bilirubin level and non-alcoholic fatty liver disease

Objective To investigate the relationship between serum bilirubin level and non-alcoholic fatty liver disease(NAFLD). Methods Four hundred and sixty-two patients with NAFLD and 462 healthy controls were selected from the healthy physical examinees from Jan. 2013 to Jun. 2013 were enrolled into this study. The differences in height,weight,blood pressure,total serum bilirubin,direct blirubin,indirect bilirubin,alanine aminotransferase(ALT),aspartate aminotransferase(AST),triglyceride(TG),total cholesterol(TC),fasting blood glucose,uric acid were compared between two groups and the correlation between serum bilirubin and NAFLD was analyzed. Results The body mass index,blood pressure,ALT,AST,TG,TC,fasting blood glucose,uric acid of the NAFLD group were higher than those of the control group( P 0. 01); total serum bilirubin,direct blirubin,indirect bilirubin of the NAFLD group were lower than those of the control group(P 0. 01); the increase in the risk of NAFLD was related to the decrease of total serum bilirubin level( OR = 0. 897,P 0. 01). Conclusion Total serum bilirubin level is related to NAFLD. As total serum bilirubin level decreases,the risk of NAFLD tends to increase.