2014•Practical Journal of Cardiac Cerebral Pneumal and Vascular DiseaseRequires access
Effect of Duloxetine Combined with Cognitive Therapy on Persistent Somatoform Pain Disorder
Wang De-su
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Abstract
Objective To observe the effect of duloxetine combined with cognitive therapy on persistent somatoform pain disorder( PSPD). Methods 70 patients with PSPD admitted to our hospital from August 2012 to March 2013 were randomly divided into groups study and control. Both groups were given duloxetine,starting dose was 30 mg / d; study group was given cognitive therapy on the basis of control group. The pain effect was evaluated by pain scale( MOSPE) after 6 weeks treatment. Both were applied Hamilton depression scale( HAMD) before and 2,4,6 weeks after treatment. Results The efficacy of groups study and control was 82. 9%(29 /35) and 77. 1%(27 /35). There was no satistically significant difference in efficacy between two groups( χ2= 0. 36,P 0. 05). HAMD score of study group was lower than that of control group 4,6 weeks after treatment( P 0. 05). Conclusion Duloxetine has better effect and tolerance on PSPD,and is helpful to improve the depressive symptoms when combined with cognitive therapy.