The effect of comprehensive intervention on abnormal glucose metabolism process in the elderly

Objective To analyze the effect of comprehensive intervention on abnormal glucose metabolism progression in the elderly.Methods Comprehensive intervention in the retired elderly cadres with the cardiovascular disease risk factors were conducted from the year of 2002 to 2006,549 elderly cadres with normal glucose tolerance(NGT) and 110 ones with impaired glucose regulation(IGR) were follow-up for four years.Results The average levels of blood pressure,TC,LDL-C,TG and BMI were reduced significantly(P0.01) at the end of comprehensive intervention.Among the 549 subjects with NGT,30.97% had progressed to IGR.Among the subjects developed to IGR,the progression rates of IFG,IGT,and combined IFG and IGT(IFG/IGT) were 6.74%,16.39%,and 7.83%,respectively.The progression rates of IGT was significantly higher than that of IFG and IFG/IGT(P0.01).The prevalence rate of IFG according to the new IFG criteria was 1.1 times the rate of the old IFG criteria,the progression rate of IFG1 with 4.55% was significantly higher than that of IFG2 with 2.19%(P0.05).At baseline,110 subjects had IGR.At the end of follow-up,16.28% had progressed to diabetes from IFG,whereas 19.61% to diabetes from IGT,and there was no statistically significant difference(P0.05).8.70% had progressed to diabetes from IFG1,while 25.00% to diabetes by IFG2(P0.05).43.75% had progressed to diabetes by IFG-IGT,and the progression rate from IFG-IGT to diabetes was significantly higher than that of IFG or IGT(P0.05).The cumulative incident of diabetes from IGR at baseline was more than that of the newly acquired IGR from NGT(21.82 vs.3.28%,P0.01).Conclusion The progression rate of IGT from NGT is significantly higher than that from IFG in elderly,and the progression rate from IFG-IGT to diabetes is significantly higher than isolated IFG or IGT,the cumulative incident of diabetes of IGR at baseline is significantly more than that of the newly acquired IGR from NGT.