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2009•The Journal of Medical Theory and PracticeRequires access

Clinical Observation of Propafenone in Treating Paroxysmal Supraventricular Tachycardia

Zhou Zhi-hu

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Abstract

Objective:To evaluate the therapeutic and side effect of paroxysmal supraventricular tachycardia(PSVT).Methods:40 patients with PSVT were recruited.Under electrocardiogram and BP monitoring,propafenone was prescribed at first dose of 70mg by intravenous injection during 10 minutes.If the heart sinus rhythm couldn't be recovery after the first dose,35 mg of propafenone could be duplicated after a 10 minutes interval and the maximum cumulative dosage was 175mg.After the heart sinus rhythm was recovery,oral propafenone was prescribed 150~200mg three times a day.All the patients were followed for response rate and relative side effect.Results:31 cases(31/40,77.5%) were recovery to sinus rhythm after the first dose and 6 cases recovery after boost.The total response rate was 92.5%(37/40).Maintaining therapy for at least half year,there was no recurrence or serious side effect.Conclusion:Propafenone is effective and safe in treating PSVT.

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What this paper is about

Objective:To evaluate the therapeutic and side effect of paroxysmal supraventricular tachycardia(PSVT).Methods:40 patients with PSVT were recruited.Under electrocardiogram and BP monitoring,propafenone was prescribed at first dose of 70mg by intravenous injection during 10 minutes.If the heart sinus rhythm couldn't be recovery after the first dose,35 mg of propafenone could be duplicated after a 10 minutes interval and the maximum cumulative dosage was 175mg.After the heart sinus rhythm was recovery,oral propafenone was prescribed 150~200mg three times a day.All the patients were followed for response rate and relative side effect.Results:31 cases(31/40,77.5%) were recovery to sinus rhythm after the first dose and 6 cases recovery after boost.The total response rate was 92.5%(37/40).Maintaining therapy for at least half year,there was no recurrence or serious side effect.Conclusion:Propafenone is effective and safe in treating PSVT.

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Available abstract

Objective:To evaluate the therapeutic and side effect of paroxysmal supraventricular tachycardia(PSVT).Methods:40 patients with PSVT were recruited.Under electrocardiogram and BP monitoring,propafenone was prescribed at first dose of 70mg by intravenous injection during 10 minutes.If the heart sinus rhythm couldn't be recovery after the first dose,35 mg of propafenone could be duplicated after a 10 minutes interval and the maximum cumulative dosage was 175mg.After the heart sinus rhythm was recovery,oral propafenone was prescribed 150~200mg three times a day.All the patients were followed for response rate and relative side effect.Results:31 cases(31/40,77.5%) were recovery to sinus rhythm after the first dose and 6 cases recovery after boost.The total response rate was 92.5%(37/40).Maintaining therapy for at least half year,there was no recurrence or serious side effect.Conclusion:Propafenone is effective and safe in treating PSVT.

Key concepts: Propafenone, Medicine, Paroxysmal supraventricular tachycardia, Sinus rhythm, Anesthesia, Supraventricular tachycardia, Normal Sinus Rhythm, Supraventricular arrhythmia

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