Clinical observation of post-stroke depression by Buspirone combined with Escitalopram

Objective:To compare the effect and safety of Buspirone combined with Escitalopram and Escitalopram used singly in the treatment of post-stroke depression.Methods:Totally the 60 post-stroke depression patients were randomized into control group(n=30),treated with Escitalopram,and study group(n=30),treated by Buspirone combined with Escitalopram.The observation lasted 8 weeks.The therapeutic effect and safety were evaluated by the positive and negative syndrome scale of HAMD(24 items),and treatment emergent symptom scale of TESS.Results:Total effective rate of the study group was 93.3%(28/30) and with the control group 63.3%(23/30),there was a significant difference(χ2=8.91,P=0.031,P0.05),and according to HAMD total scores assessment,there was a significant difference between two groups(P0.05) after the treatment in different weekend.The difference of TESS scores between two groups was not significant.Conclusion:Buspirone combined with Escitalopram is effective and safe in the treatment of post-stroke depression.