Observation on immunogenicity of different formulation of hepatitis B vaccine in newborns

Objective To study the immune efficacy and safety of 10μg and 5μg hepatitis B vaccine in newborns and to provide the scientific basis for the adjustment of neonatal hepatitis B vaccine immunization programs. Methods The HBV antibody levels of people who inoculated various doses of hepatitis B vaccine in different time were observed when they were born with case-control study method. Serum antibody levels were detected by chemiluminescence immunoassay. Results 1 month, 6 months and 12 months after full course of inoculation of hepatitis B vaccine, non-response rate in 10μg hepatitis B vaccine was higher than that of 5μg hepatitis B vaccination group. The titer of HBsAb in 10μg hepatitis B vaccine group was higher than that of 5μg hepatitis B vaccination group. 12 months after inoculation, the titer of HBsAb in two groups were both reduced, and the positive rate of HBsAb in10μg hepatitis B vaccine group was higher than that of 5μg hepatitis B vaccination group. Conclusion The efficacy of 10μg hepatitis B vaccine group is better than that of 5μg hepatitis B vaccine group.