Clinicopathologic Significance of Expression of VEGF and Angiogenesis in Colorectal Adenocarcinoma

Objective To study the clinicopathologic significance of expression of vascular endothelial growth factor(VEGF) and angiogenesis in colorectal adenocarcinoma. Methods Immunohistochemical method was used to detect the expression of VEGF and CD34 antibody was used to measure Microvessel density(MVD),then the clinicopathologic significance was analyzed by 70 specimens of colorectal adenocarcinoma. Results No positive statistical significance was obtained in the correlation among the expression of VEGF,MVD and degree of differentiation(P0.05),but higher positive rates of VEGF proteins and higher MVD were found in the group of lymph node metastasis than those of the group without lymph node metastasis,higher positive rates of VEGF proteins and MVD in the group of serous membrane infiltration than those in the group of muscular layer infiltration.Significant difference were statistically observed by positive rates of VEGF proteins and MVD compared in different DUKES stage(P0.05,respectively).Conclusions The over-expression of VEGF and high MVD might promote the invasion and metastasis of colorectal carcinoma.