Protective effect of rosiglitazone on severe acute pancreatitis

Objective:To investigate the protective effect and mechanism of rosiglitazone on severe acute pancreatitis(SAP).Methods:Seventy-two SD rats were randomized into three groups:sham operation(SO)group,SAP group and rosiglitazone-pretreated group.The model of SAP was induced by retrograde injection of 5% sodium taurocholate into the bili-pancreatic duct in SD rats,rosiglitazone-pretreated group was given by 10 mg/kg rosiglitazone intraperitoneally 30 min before inducing SAP.Rats in the three groups were killed at 3,6,12 hours after induction of the model.The levels of amylase,TNF-α,IL-6 in plasm were measured.The myeloperoxidase(MPO)of pancreas were also measured.The histopathological changes and the histologic scores of pancreatic tissue were evaluated.Results:Compared with SO group,the levels of plasm amylase,TNF-α,IL-6,the intrapancreatic MPO significantly increased in SAP group(P0.05),and the histologic scores of pancreatic tissue significantly decreased in SAP group(P0.01),and the pancreas injury were aggravated gradually.Compared with SAP group,the levels of plasm amylase,TNF-α,IL-6,intrapancreatic MPO significantly decreased in rosiglitazone-pretreated group at 3 h,6 h,12 h(P0.05),the pancreatic histopathologic scores significantly decreased in rosiglitazone-pretreated group at 6 h,12 h(P0.05),and the severity of pancreas injury also significantly decreased in rosiglitazone-pretreated group.Conclusions:Rosiglitazone might have therapeutic effect on SAP by decreasing the production of TNF-α and IL-6.