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2003•Zhōnghuá yàoxué zázhìRequires access

Study on screening the cyclooxygenase-2 inhibitor by in vitro method

Zhijun Wang

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Abstract

OBJECTIVE To establish the assay model of cyclooxygenase-2 activity and provide the screening method of NSAIDs.METHODS Observations were made that cyclooxygenase-2 was induced in the exist of FCS.The inhibitory potency of the compounds was evaluated by determining the concentration of PGE 2.Rofecoxib employed as the reference drug was used to evaluate whether this method was available to determine the inhibitory potency of cyclooxygenase-2.RESULTS The results proved that rofecoxib can inhibit the activity of cyclooxygenase-2.CONCLUSION The in vitro method can be used to screen the cyclooxygenase-2 inhibitor.

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What this paper is about

OBJECTIVE To establish the assay model of cyclooxygenase-2 activity and provide the screening method of NSAIDs.METHODS Observations were made that cyclooxygenase-2 was induced in the exist of FCS.The inhibitory potency of the compounds was evaluated by determining the concentration of PGE 2.Rofecoxib employed as the reference drug was used to evaluate whether this method was available to determine the inhibitory potency of cyclooxygenase-2.RESULTS The results proved that rofecoxib can inhibit the activity of cyclooxygenase-2.CONCLUSION The in vitro method can be used to screen the cyclooxygenase-2 inhibitor.

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Available abstract

OBJECTIVE To establish the assay model of cyclooxygenase-2 activity and provide the screening method of NSAIDs.METHODS Observations were made that cyclooxygenase-2 was induced in the exist of FCS.The inhibitory potency of the compounds was evaluated by determining the concentration of PGE 2.Rofecoxib employed as the reference drug was used to evaluate whether this method was available to determine the inhibitory potency of cyclooxygenase-2.RESULTS The results proved that rofecoxib can inhibit the activity of cyclooxygenase-2.CONCLUSION The in vitro method can be used to screen the cyclooxygenase-2 inhibitor.

Key concepts: Cyclooxygenase, Rofecoxib, Potency, In vitro, Pharmacology, Chemistry, Inhibitory postsynaptic potential, Medicine

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