Clinical value of serum Cystatin C for detection of renal function in patient underwent portacaval anastomosis

Objective To investigate the diagnostic value of serum Cystatin C for monitor of renal function in patient underwent portacaval anastomosis.Methods 24 hours Creatinine Clearance(CCr),serum level of Cystatin C(Cys C) and serum Creatinine were measured in 113 patients performed portacaval anastomosis.Chi-square test,Pearson correlation test as well as ROC curve were utilized to evaluate the diagnostic significance of Cys C.Results 36 out of 113 patients suffered the renal injury.Among these 36 patients,29 cases were associated with the increase level of CysC,whereas 17 cases were turn out to be the elevation of SCr level.Cys C and SCr both significantly inverse correlated with CCr(CysC: r=-0.711,P0.001;SCr:r=-0.596, P0.001),However,coefficient value of Cys C to CCr was significantly higher than that of SCr.Moreover,using ROC curve,Cystatin C was diagnostically superior to creatinine [area under the curve(AUC) for cystatin C 0.824 vs(AUC) for creatinine 0.690].Conclusion Cystatin C is a more accurate marker of renal injury in patient underwent portacaval anastomosis.Detection of Cys C level in these patients could contribute to the treatments of renal injury or hepatorenal syndrome.