Clinical value of serum Cystatin C for detection of renal function in patient after liver resection

Objective To investigate the clinical value of serum Cystatin C(Cys C) for monitoring of renal function in patient after liver resection.Methods 24-hours creatinine clearance(CCr),serum level of Cys C and serum creatinine(SCr) were measured in 141 patients after liver resection.x2 test,Pearson correlation test and ROC curve were utilized to evaluate the diagnostic significance of Cys C.Results Thirty-two out of 141 patients suffered the renal injury.Among these 32 patients,level of Cys C increased in 28 cases,whereas the elevation of SCr level in 15 cases were turn out.Cys C and SCr both significantly inversely correlated with CCr(CysC: r=-0.742,P0.001;SCr: r=-0.503,P0.001).However,coefficient of Cyst C to CCr was obviously higher than that of SCr.Moreover,using ROC curve,Cystatin C was diagnostically superior to SCr(area under the curve for cystatin C 0.815,AUC for creatinine 0.643).Conclusion Cys C is a more accurate marker of renal injury in patients after liver resection.Detection of Cys C level in these patients can contribute the prevention of renal injury or hepatorenal syndrome.