Effects of telmisartan on the left ventricular remodling in SHR

Objective To investigate the effects of Telmisartan on the left ventricular remodeling in spontaneously hypertensive rats. Methods 16 male SHR at 16 weeks of age were randomly divded into treated group(receiving telmisartan 10 mg/kg per day)and SHR-control group. Another 8 WKY rats were chosen as healthy contro1led group.After 8 weeks,all the rats were killed. The thickness of left ventricle were measured and the left ventricle muscle weight(LVW) also were measured to calculate the LVW/BW. Myocardial collage was stained and the interstitial collagen volume fraction(CVF)and the perivascular circumferential collagen area(PVCA) were determined by quantitative morphometry. Electron microscope was used to study the myocardial pathologic and ultrastructural changes. Results Compared with WKY group,the SBP,LVW/BW,thickness of left ventricle,CVF and PVCA were significantly higher in SHR group(P0.01),and substantially reduced in treated group than that in SHR group(P0.01). Meanwhile, pathologic and ultrastructure observation demonstrated that the treated group reversed left ventricular remodeling effectively. Conclusion Telmisartan can decrease blood pressure and ameliorate left ventricular remodeling effectively.