Apparent diffusion coefficient value in diagnosis of liver cirrhosis and hepatocellular carcinoma

Objective To evaluate the diagnostic value of apparent diffusion coefficient (ADC) values in liver cirrhosis and hepatocellular carcinoma by using SENSE technique. Methods Diffusion weighted imaging (DWI) was performed in 30 healthy volunteers, 30 hepatocellular carcinoma and 30 liver cirrhosis. All data were acquired by using PHILIPS software on the ADC imaging. Results The DWI and ADC imaging were successfully acquired from all healthy control and 60 patients. When b values were 300, 1000, 1500 s/mm2 respectively, the ADC values of normal liver, cirrhotic liver, and hepatocellular carcinoma were (1.520±0.169), (1.200±0.132), (1.068±0.118)×10 -3mm2/s; (1.305±0.1181), (1.137±0.124), (1.006±0.107)×10 -3mm2/s; (1.163±0.206), (0.898±0.155), (0.803±0.140)×10 -3mm2/s, respectively. The ADC values of the same organ showed significant differences under different b values (P0.05), and the ADC values of three different groups showed significant differences under the same b value (P0.05). Conclusion The ADC value plays an important role in the diagnosis of hepatocellular carcinoma and liver cirrhosis.