Application of Diffusion Weighted Imaging in Liver Cirrhosis and Hepatocellular Carcinoma at 3.0 T Magnetic Resonance

Objective To evaluate the diagnostic value of diffusion weighted imaging(DWI) at 3.0 T magnetic resonance in liver cirrhosis and hepatocellular carcinoma.Methods DWI was performed in 10 healthy volunteers,21 patients with liver cirrhosis and 30 patients with hepatocellular carcinoma at 3.0T magnetic resonance. DWI and ADC values in normal liver, liver cirrhosis and hepatocellular carcinoma were analysed.The diagnostic sensitivity and specificity of ADC values in normal liver, liver cirrhosis and hepatocellular carcinoma were also analysed.Results When b value was 100 s/mm2,the ADC values of normal liver were higher than liver cirrhosis, hepatocellular carcinoma(P0.05),but there was not significance between liver cirrhosis and hepatocellular carcinoma(P0.05).When b value was 300 s/mm2,1000 s/mm2,the ADC values of three groups had significant differences(P0.01). When b value was 300 s/mm2, the diagnostic sensitivity and specificity were 82.6% and 100% in liver cirrhosis ,95.2% and 90.4% in hepatocellular carcinoma ,respectively. When b value was 1000 s/mm2, the diagnostic sensitivity and specificity of ADC values were 86.9% and 100% in liver cirrhosis,95.2% and 66.7% in hepatocellular carcinoma,respectively. Conclusion DWI at 3.0 T magnetic resonance in examination of liver could synthetically and quantitatively analyze the rule of ADC values in liver cirrhosis and hepatocellular carcinoma.