2002•Zhonghua putong waike zazhiRequires access

Effect of hepatocyte growth factor on hepatocytes after partial hepatectomy in cirrhotic rats

Zhibin Yan

Abstract

Objective To study the effect of hepatocyte growth factor (HGF) on hepatocytes after partial hepatectomy in chronic liver injury rats.Methods 30% hepatectomy was performed in rats with cirrhosis induced by CCL 4 and alcohol,and subcutaneously injection of cow HGF into intraabdomen was done with different dosages.Results Small dose (0.16mg·100g -1d -1)of HGF did not stimulate liver regeneration or enhance liver function after partial hepatectomy in cirrhotic rats.Large dose (1.3mg·100g -1d -1) of HGF stimulated liver regeneration and enhanced liver function after partial hepatectomy in cirrhotic rats(P0.05).Conclusions These results demonstrate that injection of large dose HGF can stimulate the regeneration of remnant liver and improve liver funtion in rats with cirrhosis after partial hepatectomy.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Medicine, Hepatectomy, Liver regeneration, Cirrhosis, Hepatocyte growth factor, Hepatocyte, Internal medicine, Liver function