2001•Chinese Journal of Clinical NeurosciencesRequires access

Study of Time of Sublethal Cerebral Ischemia and Time of Protective Effects

Jing Zhang

Abstract

Aim:To investigate time of sublethal cerebral ischemia and time of protective effects of CA 1 neurons.Methods:Bilateral occlusion of common carotid arteries and the morphological changes of the neurons in gerbil hippocampal tissue slices were observed by light microscopy.Results:Pretreatment with 1 min bilateral carotid artery occlusion did not produce protective effects. 2 min pretreatment followed by 3.5 min occlusion resulted in the complete destruction and protection of CA 1 neurons at 6h,15d and 1d,3d,5d,7d interval respectively.Conclusion:Pretreatment with brief ischemia leads to complex responses of the brain to secondary ischemic insult and protective effects at intervals of 1～7 d

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Key concepts: Gerbil, Ischemia, Medicine, Occlusion, Carotid arteries, Hippocampal formation, Anesthesia, Common carotid artery