2000•Journal of Heze Medical CollegeRequires access

Effects of Enalapril on Hemodynamics and Ventricular Morphology After Acute Myocardial Infarction in Rats

Jian Tian

Abstract

Objective To investigate the mechanism of the left vetricular remodeling after acute myocardial infarction,we examined the effects of 3 weeks treatment with an angiotesin converting enzyme inhibitor,Enalapril,on hemodynamics and cardic morphology in myocardial-infarcted rats.Methods The rats were divided into three groups:MI group, MI Enalapril treated group and SO,sham-operated group.Results Enalapril had special effects on ventricular geometry in rats with infarction,which resulted in decreasing radius of left ventricular cavity 14.1% compared with MI rats,the LVEDP were decreased significantly(P0.01).Conclusion The results showed the use of Enalapril after MI may improve the cardiac function.

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Key concepts: Enalapril, Medicine, Myocardial infarction, Preload, Cardiology, Hemodynamics, Internal medicine, Enalapril Maleate