Effects of Enalapril and Captopril on Morphology After Acute Myocardial Infarction in Rats

Objective To investigate the mechanism of the left vetricular remodeling after acute myocardial infarction,through observing the effects of 3 weeks' treatment with two angiotesin converting enzyme inhibitors, Enalapril and Captopril,on morphology in myocardial-infarcted rats. Methods The rats were divided into three groups:SO,sham-operated;MI; MI Enalapril treated and MI captopril treated. Enalapril and Captopril were given three days before infarction. Results Enalapril and Captopril had special effects on ventricular geometry in rats with infarction,which resulted in decreasing radius of left ventricular cavity by 13.2% and 12.7% respectively compared with MI rats,but the LV weight/bodyweight and the LV chamber radius had been increased 10.4% and 24.5% respectively in MI campared with SO, MI Enalapril treated and MI captopril treated.There were no differences (P0.05). Conclusion The use of Enalapril and Captopril after MI may relieve the left ventricular remodeling and improve the cardiac function,and the two angiotesin converting enzyme inhibitors have no differences.