Survivin expression in pancreatic carcinoma and its relation with prognosis

Objective:To investigate the survivin expression in pancreatic carcinoma and its relation with prognosis of the patients.Methods:The survivin expression in the primary pancreatic cancer and their adjacent non-tumorous tissues resected from 55 patients were detected by immunohistochemical staining.The relations of survivin expression with the clinicopathologic factors and survival of the patients were analyzed.Results:The high survivin expression rate in the pancreatic cancer tissues was 65.5%(36/55),and all the adjacent non-tumorous pancreatic tissues presented low survivin expression.The 1-,3- and 5-year overall survival rate for the entire group of patients was 50.9%,30.9% and 1.8%,respectively.The survivin expression was not related to gender,age,or tumor location and size(all P0.05),while it was significantly associated with degree of dif erentiation,lymph node metastasis and TNM stages(all P0.05).Cox proportional hazards regression analysis identified that survivin expression along with degree of differentiation and lymph node metastasis were independent risk factors af ecting prognosis of the patients(all P0.05).Survival analysis demonstrated that the survival rate in group of patients with high survivin expression was significantly lower than that in group of patients with low survivin expression(P0.05).Conclusion:The survivin expression is closely related to the prognosis of the pancreatic cancer patients,and those with high survivin face a poor prognosis.