The Application of GnRH-antagonist to Mediate Ovarian Hyperstimulation

Objective: To compare the clinical outcomes of protocols with GnRH antagonist and agonist for ovarian stimulation.Methods: To observe endometrial width and E2 concentrations on the day of HCG trigger,fertilization,usable embryo percentage,clinical pregnancy rate,implantation,miscarriage rates between GnRH antagonist and agonist groups,between the prengnancy and non-pregnancy group.Results: The total clinic characters are similar beteen GnRH antagonist and agonist group.E2 concentrations on the day of HCG trigger and usable embryo percent were significantly higher in GnRH antagonist pregnancy group compared with the non-pregnancy group.Conclusion: The slow or pausal increase of E2 concentrations on the late luteal and the low E2 concentrations on the day of HCG.trigger,who indicate inferior pregnancy outcomes.Further studies will be needed for confirmation weather GnRH antagonist was harmful to the endometrium and embryos.