2012•Acta Endocrinologica (Bucharest)Requires access
The Effect of GnRH Agonist versus GnRH Antagonist on Pregnancy Rate
Ercan Baştu
Open publisher page 0 citations
Abstract
Context. Comparison of GnRH analogues and their impact on IVF treatment to improve pregnancy outcome. Objective. To compare the effects of GnRH agonists and GnRH antagonists on pregnancy rates. Design. A total of 458 women who had embryo transfers completed were analyzed retrospectively in a university hospital setting. Methods. Comparative data were gathered on pregnancy rates, FSH dosage, and number of follicles, retrieved oocytes and embryos. Results. The use of GnRH agonist showed a strong association with the number of follicles (GnRH antagonist: 11.45; GnRH agonist: 15.17), oocytes retrieved (GnRH antagonist: 10.66; GnRH agonist: 13.68) and embryos transferred (GnRH antagonist: 2.54; GnRH agonist: 2.89) (p 5 mIU/mL pregnancy (GnRH antagonist 30.8%; GnRH agonist: 21.8%) (p<0.05). Ongoing pregnancy rates between the two GnRH analogues showed no