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Effects of Genistein on morphological changes in cultured hippocampal neurons following β-Amyloid_((25-35))-induced apoptosis

Si Wang

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Abstract

AIM:To investigate the neuroprotective effect of Genistein on morphological changes in cultured hippocampal neurons following β-Amyloid(25-35)-induced apoptosis.METHODS:The model of damage was induced by Aβ25-35 and the changes of cell morphology were observed.Apoptosis in hippocampal neurons induced by Aβ25-35 was detected with hoechst33342 and PI co-staining method.NSE and Tunel double-staining assay were also conducted.RESULTS:Compared with that in Aβ25-35 only group,the morphology damage of hippocampal neurons in Genistein model group was less severe and apoptosis in Genistein model group was obviously lower.CONCLUSION:Genistein,with some neuroprotective or anti-apoptotic effects,plays an important role in up-regulating the hippocampal neuronal survival during the process of Aβ25-35-induced damage.

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AIM:To investigate the neuroprotective effect of Genistein on morphological changes in cultured hippocampal neurons following β-Amyloid(25-35)-induced apoptosis.METHODS:The model of damage was induced by Aβ25-35 and the changes of cell morphology were observed.Apoptosis in hippocampal neurons induced by Aβ25-35 was detected with hoechst33342 and PI co-staining method.NSE and Tunel double-staining assay were also conducted.RESULTS:Compared with that in Aβ25-35 only group,the morphology damage of hippocampal neurons in Genistein model group was less severe and apoptosis in Genistein model group was obviously lower.CONCLUSION:Genistein,with some neuroprotective or anti-apoptotic effects,plays an important role in up-regulating the hippocampal neuronal survival during the process of Aβ25-35-induced damage.

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Available abstract

AIM:To investigate the neuroprotective effect of Genistein on morphological changes in cultured hippocampal neurons following β-Amyloid(25-35)-induced apoptosis.METHODS:The model of damage was induced by Aβ25-35 and the changes of cell morphology were observed.Apoptosis in hippocampal neurons induced by Aβ25-35 was detected with hoechst33342 and PI co-staining method.NSE and Tunel double-staining assay were also conducted.RESULTS:Compared with that in Aβ25-35 only group,the morphology damage of hippocampal neurons in Genistein model group was less severe and apoptosis in Genistein model group was obviously lower.CONCLUSION:Genistein,with some neuroprotective or anti-apoptotic effects,plays an important role in up-regulating the hippocampal neuronal survival during the process of Aβ25-35-induced damage.

Key concepts: Genistein, Hippocampal formation, Neuroprotection, Apoptosis, TUNEL assay, Biology, Programmed cell death, Staining

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Effects of Genistein on morphological changes in cultured hippocampal neurons following β-Amyloid_((25-35))-induced apoptosis — Research Paper | ScholarLens