2008•Medical Journal of National Defending Forces in Northwest ChinaRequires access

Toxicity of methamphetamine on hippocampal neurons in vitro

Ping Ding

Abstract

Objective:To investigate the mechanism of methamphetamine(MA)-induced neuronal damage with hippocampal neurons in vitro culture.Methods:The hippocampal neurons from rats were treated with MA at 0,0.8,1.6,3.2,6.4 and 12.8 mmol/L respectively for 48 h.The viability of neurons was examined by MTT assay,and the morphological changes were observed by inverted microscope and electron microscope respectively.Results:MA induced the apoptosis of neurons in dose-dependent manner.There was significant difference between the MA-treated group and the control group in the apoptosis rate of hippocampal neurons(P0.01).Conclusion:MA at certain concentration is cytotoxic on cultured hippocampal neurons and can induce apoptosis in dose-dependent manner.

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Key concepts: Hippocampal formation, Apoptosis, In vitro, Methamphetamine, Electron microscope, Chemistry, Toxicity, Neuron