Comparison of the cardiovascular response at extubation period of general anesthetic postoperation using remifentanil only and remifentanil combined with fentanyl

Objective To compare the cardiovascular response at extubation period of general anesthetic postoperation using remifentanil only and remifentanil combined with fentanyl.Methods Forty ASA class Ⅰor Ⅱpatients of laparoscopic cholecystectomy were randomly and equally divided into remifentanil group(R) and fentanyl-remifentanil group(FR).Remifentanil 1 μg/kg in group R and fentanyl 5μg/kg in group FR combined with midazolam 0.05 mg/kg,vecuronium 0.1 mg/kg and propofol 1.5 mg/kg were used for anesthesia induction.0.2μg·kg-1·h-1 dose of remifentanil and 5-6mg·kg-1·h-1 dose of propofol were infused to maintain anesthesia.MAP,HR and the revival time were observed.Results MAP and HR in group R significantly rised compared with group FR at the time of extubation,1 minute and 5 minutes after extubation(P0.05).The time of breathing recovery,eye opening,extubation had no significant difference in two groups.Conclusion Fentanyl combined with remifentanil can depress the cardiovascular response at extubation period of general anesthetic postoperation more effectively than remifentanil only,meanwhile,does not prolong revival time.