Therapeutic effect observation of thrombolysis with rt-PA intravenous in hyper acute cerebral infarction

Objective To assess the efficacy and safety of thrombolysis with rt-PA intravenous in hyper acute cerebral infarction(ACI). Methods 74 patients within 6 hours after the onset of stroke were enrolled in our trial and every patient was given rt-PA 50mg intravenously. The NIHSS scores were used before thrombolysis and at 30 min, 24 h, 14 d, 3 months after thrombolysis. At 3 months, the mRS score, BI scale, the incidence of symptomatic intracranial hemorrhage (sICH) and the mortality were calculated to assess the efficacy and safety. Results The NIHSS scores were improved at each time point (all P0.01). At 3 months, there were 31 patients (41.9%) with low NIHSS score (≤1), 39 patients (52.7%) with low mRS (0~1) and 33 patients (44.6%) with high BI scale (95~100). The rate of ICH was 6.8% (5 cases) within 36 h and 4.1% (3 cases) during 36 h~72 h. 9 patients (12.2%) died within 3 months. Conclusion ACI patient given 50 mg of rt-PA within 6 hours of onset is efficient and safe.