Expression and clinical significance of NF-κB and ICAM-1 in non-small cell lung cancer

[ Objective] To investigate the clinical significance of NF-κB and ICAM-1 in non-small cell lung cancer (NSCLC). [Methods] The expression of NF-κBp65 and ICAM-1 were detected by SABC immunohistochemistry method in paraffin-embeded sample from 40 cases of NSCLC to analyzed the correlation between NF-κBp65, ICAM-1 and kinds of clinical factors(including sex, age, histological type, cell differentiation, tumor size, TNM stage, cigarette index and distant metastasis). 40 cases of non-malignant tissue from lung lesions were employed as a control group. [Results] NF-κBp65 and ICAM-1 were evidently expressed and were more strongly expressed in lung cancer than in non-malignant tissue (P 0.05). In lung cancer, the expression of NF-κBp65 and ICAM-1 in adenocarcinoma was stronger than in squamous cell carcinoma. The expression of ICAM-1 in poorly differentiated tumor tissues was stronger than in well differentiated tumor tissues (P 0.05). NF-κBp65 and ICAM-1 were more strongly expressed in lung cancer with distant metastasis than those without distant metastasis (P 0.05). The expression of NF-κBp65 and ICAM-1 were not related to age, sex, tumor size, stage and cigarette index (P 0.05). In NSCLC tissue, there was positive correlation between NF-κBp65 and ICAM-1 (P0.05). [Conclusions] It was strongly expressed the expression of NF-κBp65 and ICAM-1. The expression of NF-κBp65 and ICAM-1 had relation with the invasion and metastasis of lung cancer. And in NSCLC tissue, there was positive correlation between NF-κBp65 and ICAM-1.