Observation of Changes in Peripheral Lymphocyte Subsets by Flow Cytometry in Patients with Non-small Cell Lung Cancer with Docetaxel Combination with Cisplatin Regimen

Objective To evaluate the changes in peripheral lymphocyte subsets by flow cytometry of docetaxel combination with cisplatin regimen in patients with advanced non-small cell lung cancer.Methods A total of forty-seven patients with a pathologic diagnosis enrolled in the study were treated with paclitaxel 25mg/m2 infusion for 1h on day 1,8,15 and cisplatin 25mg/m2 infusion on day 1 to 3.It was repeated every 28 days.Every patient must be treated for two cycles then evaluated with the flow cytometry for CD3+、CD4+、CD8+、CD16+56+、CD19+.Results The expressive rates of CD4+,CD16+56+ and CD4+/CD8+ in peripheral blood were higher in post-treat-ment patients than in pre-treatment samples(P0.05).No evident case of changes of CD3+、CD8+、CD19+ positive cell percentage were observed after chemotherapy(P0.05).Conclusion Docetaxel combination with cisplatin regumen for advanced non-small cell lung cancer can activate patient’s immune function.