Study on preparation of the Metronidazole Buccal Tablets

Objective:To prepare the metronidazole buccal Tablet.Methods:By using orthogonal design,different formula and active ingredients according to the characteristics of buccal tablets were evaluated by the effect of the taste,appearance characteristics,disintegrating time,hardness and in vitro dissolution.Results:The optimal formulation composed of metronidazole 200 g,sucrose powder 40 g,mannitol 10 g,aspartame 20 g,4 percent Lemon Flavor,0.2 percent sodium carboxymethyl starch,and 0.5 percent magnesium stearate.Conclusion:The proposed process method is reasonable and favorable for industrial production.