2013•Chinese Journal of General PracticeRequires access

Study on Neutralizing Antibody of Enterovirus 71 in Fuyang Region

Zhao Yon

Abstract

Objective To investigate the neutralization indices of enterovirus 71(EV71) in children with infected hand-foot-mouth disease(HFMD).Methods The serum samples were collect from HFMD children from April to June,2008.The EV71 neutralizing antibody titers were tested with assay.Results A total of 113 serum samples were collected from 83 children.①the sero-conversion rate were 96% at 1-3 days after symptom appearing;②neutralizing antibody manifested a dynamic change from low to higher titer with the disease development,and the geometric mean titer(GMT) was 388.3;③the GMT of severe cases(367.2) was not significantly lower than that of mild cases(421.3).Conclusion The neutralizing antibody as a humoral immunity index may provide valuable information for understanding and control of EV71 HFMD.

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Key concepts: Enterovirus 71, Medicine, Neutralizing antibody, Titer, Antibody, Foot-and-mouth disease, Hand-foot-and-mouth disease, Antibody titer