2000•Archives of Razi InstituteRequires access
Neutralizing Antibody Response in Cattle Following Vaccination against Foot-and-Mouth Disease
Kaveh Haratian, Mehrdad Roustaei, Homayoon Mahravani, Mandana Salehizadeh, Akhavizadegan
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Abstract
Summary 450 paired serum samples were taken before and after administration of an inactivated foot - and - mouth disease vaccine, containing A-Mardabad and O1 virus strains analyzed for presence of neutralizing antibodies. Serum neutralization tests were performed in BA cell culture employing equal volume of serial two-fold dilutions of each of the previously inactivated serum against 100 TCID50 of each virus strain. The results showed that 93.99% and 95.54% of tested sera did not have a protective level of neutralizing antibodies (titer of 16 or more) against A-Mardabad and O1 strains, respectively. A good increase in the antibody titers was observed in 85.36% and 90% of the vaccinated cattle against the field strains of the above mentioned viruses, respectively. This study indicates that the footand-mouth disease vaccine, which produced by Razi Vaccine & Serum Institute, is a reliable one to be used for control of the disease in Iran.