Clinical application of serum marker HE4 in diagnosis and treatment of endometrial cancer

To investigate the expression of human epididymis protein 4(HE4) in the serum of patients with endometrial cancer and its relative clinical significance,the serum levels of HE4 in 66 cases with endometrial cancer,12 cases with endometrial atypical hyperplasia,37 cases with uterus benign tumor and 36 cases of healthy control were determined.In addition,11 follow-up cases after endometrial cancer surgical resection was measured by enzyme-linked immunosorbent assay(ELISA).The results showed that,the concentration of HE4 was higher in the serum of patients with endometrial cancer,compared with healthy controls and patients with benign tumor(P0.05);the expression of HE4 in endometrial cancer increased with the stage progression with statistical significance(χ2=11.89,P0.01);HE4 concentration in the serum was obviously lower after surgical resection,compared with that before operation(P0.01).HE4 may act as a serum marker for endometrial cancer,and useful for diagnosis,and evaluation of disease progression and prognosis.