Distribution Characteristics and Resistance Analysis of Clinical Isolates of Enterococcus

Objective: To investigate the distribution characteristics and drug resistance of our hospital clinical isolates of enterococcus, and provide the basis for the clinical use of drugs. Methods: Enterococcus distribution and susceptibility results of all clinical isolates in our hospital from January 2010 to December 2012 were retrospectively analyzed. Results: 242 strains of Enterococcus were isolated from clinical, and Enterococcus faecalis separation rate(55.0 %) was higher than Enterococcus faecium(40.9 %), while Enterococcus faecium separation rate tended to increase. The Enterococcus was main isolated from source of specimen urine(62.9 %),secretions(10.3 %), blood(6.9 %). Enterococcus was sensitivity to Vancomycin, Teicoplanin highest, which was higher than 90 %.Seven strains of Vancomycin- resistant Enterococcus(VRE) were detected, which were five of them at the same time resistant to high concentrations of Aminoglycoside antibiotics(HLAR). The resistance rates of Enterococcus to Clindamycin, Sulfamethoxazole,Amikacin, Gentamicin, Tobramycin, Oxacillin, Cefoxitin were the highest, all of them were higher than 95 %. The resistance rates of Enterococcus faecium to Penicillin, Ampicillin, Erythromycin, Nitrofurantoin, Ciprofloxacin were higher than Enterococcus faecalis, but the resistance rates to Tetracycline, Quinuperistin/Dalfopritin were Lower than Enterococcus faecalis. Conclusion: Enterococcus is important pathogen of clinical infection, and has multiple drug resistance, Enterococcus faecium and Enterococcus faecalis resistance level is quite different, and clinical rational selection of antibiotics should be based on susceptibility results.