Influence of local mechanical injury to the endometrium in the the clinical pregnancies and live births in assisted reproductive technology

Objective:To explore the posssibility that the local mechanical injury to the endometrium may increase the incidence of embryo implantation,clinical pregnancy and live births in assisted reproductive technology.Methods: The patients undergoing 476 embryo transfer (ET) cycle were conducted local mechanical injury to the endometrium with one-off suction tubes for uterine cavity on day 3-5 of menstrual cycle.471 ET-cycle patients were not treated as control.The rates of embryo implantation,clinical pregnancy and live births in the two groups were compared.Results: There were no significant differences between the trial and control group in the rates of embryo implantation (15.6% VS 13.9%),clinical pregnancy (32.6% VS 30.8%),but the local mechanical injury to the endometrium seem to have a tendency to increase these two virables.As a result,The live birth rate was significantly improved by the mechanical injury to the endometrium (62.6% VS 49.0%).Conclusion:The local mechanical injury to the endometrium may have a tendency to increase the rates of embryo implantation and clinical pregnancy and could significantly improve the chances for live birth rate in patients undergoing IVF-ET.