2006•Journal of Jiangsu UniversityRequires access
Effects of Pioglitazone on the expression of tumor necrosis factor-α(TNF-α)in the renal of diabetic rats
Geng Hou-fa
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Abstract
Objective:To investigate the effects of Pioglitazone on the expression of tumor necrosis factor-α(TNF-α)in the renal cortex of diabetic rats.Methods: SD rats were divided into three groups randomly: normal control group,diabetic group,and diabetic group with Pioglitazone treatment.At 8th week,blood glucose,HbA1c,u-Albumin,serum creatinine,urea nitrogen and TNF-αlevel in blood plasm were detected in three groups.the expression of TNF-αmRNA was detected in renal cortex by RT-PCR. Results: Blood glucose,glycosylated hemoglobin,urine micro albumin,serum creatinine,urea nitrogen and TNF-αlevel in blood plasm and the expression of TNF-αm RNA were all increased significantly in dialetic group compared with contol group,but they were much lower in diabetic group with Pioglitazone treatment. Conclusion: Pioglitazone could obviously reduce the expression of TNF-α in renal cortex of diabetic rats and it may protect the renal.