EFFECTS OF RHBNP ON CARDIAC FUNCTION AFTER ACUTE MYOCARDIAL INFARCTION

[Objective]To assess the effects of long-term infusion of recombinant human brain natriuretic peptide(rhBNP)on cardiac function after acute myocardial infarction(AMI)in rats.[Methods]Forty-five male Sprague Dawley rats surviving AMI,which was achieved by ligating coronary artery,were randomized to AMI control group(15)or rhBNP treatment group(15). Fifteen sham-operated Sprague Dawley rats were selected to serve as non-infarction controls. Two days after surgery,intravenous infusion of rhBNP or saline(for AMI control and sham-operated groups)was started through jugular vein. After 4 weeks treatment,hemodynamic measurement was performed.[Results]Comparing with sham-operated rats,SBP,DBP,the left ventricular systolic pressure(LVSP)and the maximum rising and dropping rates of left ventricular pressure(±dp/ dt)in AMI control group were significantly reduced(all P﹤0.01),while the left ventricular end diastolic pressure(LVEDP),in AMI control group were significantly increased(all P﹤0.01). In contract,comparing with AMI control group,SBP,DBP,LVSP and ±dp/dt in rhBNP treatment group was significantly increased(all P﹤0.01),while LVEDP in rhBNP treatment group was significantly reduced(P﹤0.01).[Conclusion]RhBNP is effective in improving cardiac function after AMI in rats.