2011•Xinxueguan kangfu yixue zazhiRequires access
Effects of brain natriuretic peptide on cardiac function of rats with acute myocardial infarction
Mou Chun-ping
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Abstract
Objective:To explore effects of early recombinant human brain natriuretic peptide(rhBNP) treatment on cardiac function of rats after acute myocardial infarction(AMI).Methods:AMI model was established by ligating left anterior descending artery of rats.Survived rats were randomly divided into AMI control group(n=20) and rhBNP treatment group(n=20),and another 15 normal rats were enrolled as sham operation group.Rats in rhBNP treatment group were treated with rhBNP for a week,and AMI control group,sham operation group were treated with intravenous injection of physiological saline of same volume.Effects of rhBNP on cardiac function were observed and analyzed after two weeks.Results:Compared with sham operation group,left ventricular end-diastolic dimension [LVEDd,(4.4±0.3)mm vs.(7.7±0.3)mm] significantly increased,left ventricular ejection infraction [LVEF,(82±5)% vs.(42±10)%] and fractional shortening [FS,(50±5)% vs.(18±6)%] significantly decreased in AMI control group(P0.05);After treated with rhBNP,LVEDd [(6.4±0.4)mm],LVEF[(51±7)%] and FS[(29±7)%] significantly improved in rhBNP treatment group compared with AMI control group(P0.05).Conclusion:Early treatment with recombinant human brain natriuretic peptide can effectively improve cardiac function in rats with acute myocardial infarction.