The Relationship Between M883I Polymorphism of ATP-Binding Casette Transporter A1 Gene and Coronary Heart Disease in Uygur and Han Nationalities in Xinjiang Area

Objectives: To investigate the relationship between M883I polymorphism of ATP-binding cassette transporter A1(ABCA1) gene and coronary heart disease(CAD) in Uygur and Han nationalities in Xinjiang area.Methods: Our research included two groups,CAD group,n=358,which contained 180 Uygur patients and 178 Han patients,and Control group of non CDA individuals,n=160,which contained 65 Uygur and 95 Han subjects.PCR-restriction fragment length polymorphism was performed to analyze M883I polymorphism of ABCA1 gene in both groups for two races.Results: In both CAD group and Control group,the genotype frequency distribution and the frequency of allele for M883I polymorphism were significantly lower in Uygur than Han nationality(46.3% vs.74.2%) and(43.1% vs.66.8%),P0.01 respectively.The frequency distribution of genotype and allele were no real differences between two races,P0.05.The level of blood lipids in different genotypes of M883I polymorphism were no statistic differences between Uygur and Han races,P0.05.Conclusion: The genotype frequency distribution and the frequency of allele for M883I polymorphism of ABCA1 gene were different between Uygur and Han races.There was no correlation between M883I polymorphism with CAD and blood lipid metabolism in neither races in Xinjiang area.