The characteristics and relative factors of lymph nodes metastasis of cervical squamous cell cancer and its prognosis analysis

Objective:To investigate the relativity of several clinical and pathological parameters of cervical cancer and its lymph node metastasis,and to revealed the rule of lymph node metastasis,so as to make individual therapy methods according different parameters of lymph node metastasis.Methods:99 cases of cervical squamous cell cancer were analyzed retrospectively,which were treated by Cancer Center of Sun Yet-sen University from Dec 1993 to Dec 1996.These patients were all accepted radical surgery and(or) additional radiotherapy or chemotherapy.Results:The 5-year survival of 99 cases was 60.6%,in which the incidence of negative lymph node cases was 70.0%,but that of positive lymph node was 36.7%.Patients with late FIGO stage,lower differentiation and smaller tumor size had higher rate of lymph node metastasis,vice versa.Cases with single side or single stop positive lymph node had better prognosis that of double side or more than two stops positive lymph nodes.The prognosis of patients with positive common iliac lymph node was the worst.Further more,the 5-year survival rate of single side positive obturator lymph node was 67.0%,which was similar to that of cervical cancer with negative lymph node.The incidence of lymph node metastasis was the highest in obturator stop than any other stop.Conclusion:Lymph node metastasis is an important factor which affects the prognosis of cervical Squamous Cell Cancer.The rate of lymph node metastasis is positive related with the FIGO stage and tumor size,but is negative related with differentiation degree.Obturator lymph node may be the sentinel node.Patients with single side positive obturator lymph node have a preferable prognosis,and these patients needn't accept adjuvant therapy after radical surgery if they can be followed up closely.On the contrary,if a cervical Squamous Cell Cancer case has a positive common iliac lymph node,an adjuvant therapy may be a wisdom selection.