Application of Doppler tissue imaging to assessment of global diastolic function of left ventricle in coronary artery disease during dubitamine stress

AIM:To evaluate the application of Doppler tissue imaging (DTI) with dubitamine(DBA) stress echocardiography to assessment of global diastolic function of left ventricle for detection of coronary artery disease (CAD). METHODS:30 patients with CAD and 18 subjects of normal control group underwent dubitamine stress echocardiography,and they were given addied doses of 5,10,15,20,30 μg·kg -1 ·min -1 per 5 minutes, and their velocities of mitral valve annular were measured by DTI. RESULTS:Ea increased significantly and Ea/Aa decreased a little but not significantly in the control group after dubitamine injection. Ea increased insignificantly and Ea/Aa decreased significantly in the group with single coronary artery branch stenosis. Both Ea and Ea/Aa decreased significantly in the group with more than one coronary artery branches stenosis. Ea,Ea/Aa,ΔEa% and ΔEa/Aa% in the two CAD groups were all significantly lower than those of the control group either before or after the medication. CONCLUSION:Velocities of mitral valve annular were measured by DTI and can be used to assess global diastolic function of the left ventricle during dubitamine stress test.