2005•Journal of Wenzhou Medical CollegeRequires access

Protective effect of brain ischemia preconditioning on myocardium from ischemia-reperfusion injury.

Jing Peng-peng

Abstract

Objective: To investigate the protective effect of brain ischemia preconditioning on isolated rat heart of ischeraia-reperfusion injury. Methods: Langendorff reperfusion models of cardiac ischemic-reperfusion was established. Twenty-two male SD rats were randomly divided into three groups: ischemic/reperfusion (I/R) group, classic ischemia preconditioning (IPC) group and brain ischemia preconditioning (BPC) group. Left ventricular end-diastolic pressure (LVEDP), the recovery of left ventricular developed pressure (LVDP%), and myocardial infarct size were analyses. Results: In BPC group, LVDP% was significantly improved, and LVEDP decreased, infarct size reduced, compared with the I/R group. Conclusion: Brain ischemia preconditioning has a protective effect on myocardium from ischemia-reperfusion injury. The protective effectiveness is similar to that of heart ischemic preconditioning.

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Key concepts: Preload, Medicine, Ischemia, Ischemic preconditioning, Cardiology, Internal medicine, Reperfusion injury, Anesthesia